DR. SMALL: Let me just say there’s a lot we don’t know. But we do know that the dopamine system is involved with psychotic experiences. And also, from brain imaging studies using PET imaging, we know that often the frontal lobe of the brain shows lower glucose metabolism in these patients. And that makes sense, because the frontal lobe is the thinking brain; it is the executive branch of the brain, and so the filter is gone as a result.
Paid consultant(s) of Acadia Pharmaceuticals Inc.